Welcome! You are viewing the First and the largest LinkedIn-CRISPR Networking Group. CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) multiple short direct repeats that are found in the genomes of approximately 40% of bacteria. CRISPR functions as a prokaryotic immune system, in that it confers resistance to exogenous genetic elements.
The CRISPR system provides a form of immunity. Short segments of foreign DNA, called spacers, are incorporated into the genome between CRISPR repeats, and serve as a 'memory' of past exposures. CRISPR spacers are then used to recognise and silence exogenous genetic elements in a manner analogous to RNAi in eukaryotic organisms. CRISPRs have thus huge potential to commandeer the down-regulation, expression and importantly, the KD of eukaryotic genes.